Journal Cover: 2005

Nature Medicine Cover Image

This photomicrograph accompanied the May 2005 issue of Nature Medicine, bringing attention to an article by Wang and colleagues on the prevention of ataxia and cerebellar defects in a mouse model of Nijmegen breakage syndrome.

The cover image, courtesy of NCMIR's Thomas Deerinck and Mark Ellisman, University of California, San Diego depicts two-photon fluorescence microscopy of a mouse cerebellum section immuno-stained for the inositol 1,4,5- trisphosphate receptor (concentrated in Purkinje neurons; green), actin (red) and DNA in cell nuclei (blue).

Associated article: "An essential function for NBS1 in the prevention of ataxia and cerebellar defects"