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The National Center for Microscopy and Imaging Research (NCMIR) is located on the University of California, San Diego campus. The mission of NCMIR is to develop, refine, integrate and disseminate technologies to bridge understanding of biological systems between the gross anatomical and molecular scales and to make these technologies broadly available to biomedical researchers. NCMIR provides expertise, infrastructure, technological development, and an environment in which new information about the 3D ultrastructure of tissues, cells, and macromolecular complexes may be accurately and easily obtained and analyzed.